Can You Take Hydroxyzine During Pregnancy?

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By Dr. Joel Bernstien | Updated on Sep 11, 2023
Image for article Can You Take Hydroxyzine During Pregnancy?

Hydroxyzine should be limited during the first trimester of pregnancy.

Hydroxyzine is an antihistamine that’s used mostly as an “as-needed" medication for severe itching, anxiety, or insomnia. Antihistamines are generally considered safe in pregnancy; however, studies using hydroxyzine in rats early in pregnancy did show an increased risk of fetal abnormalities. While this hasn’t been replicated in human studies, it’s probably best to refrain from frequent use in the first trimester if possible.

This medication is used commonly in the second and third trimester for the aforementioned reasons and is generally considered safe during these portions of the pregnancy. If you’re using hydroxyzine to treat anxiety, please speak with your obstetrical provider, as there are many safe and effective ways to treat anxiety even early in pregnancy.

Pregnant woman holding her stomach on a bed with a plant in the background

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Updated on Sep 11, 2023

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Can You Take Hydroxyzine During Pregnancy?

 Joel Bernstien Profile Photo
By Dr. Joel Bernstien | Updated on Sep 11, 2023
Image for article Can You Take Hydroxyzine During Pregnancy?

Hydroxyzine should be limited during the first trimester of pregnancy.

Hydroxyzine is an antihistamine that’s used mostly as an “as-needed" medication for severe itching, anxiety, or insomnia. Antihistamines are generally considered safe in pregnancy; however, studies using hydroxyzine in rats early in pregnancy did show an increased risk of fetal abnormalities. While this hasn’t been replicated in human studies, it’s probably best to refrain from frequent use in the first trimester if possible.

This medication is used commonly in the second and third trimester for the aforementioned reasons and is generally considered safe during these portions of the pregnancy. If you’re using hydroxyzine to treat anxiety, please speak with your obstetrical provider, as there are many safe and effective ways to treat anxiety even early in pregnancy.

Pregnant woman holding her stomach on a bed with a plant in the background

Want evidence-based health & wellness advice for fertility, pregnancy, and postpartum delivered to your inbox?

Your privacy is important to us. By subscribing you agree to our Privacy Policy and Terms & Conditions.


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