Prednisone is generally considered safe for use during breastfeeding.
Based on the information available, the amounts of prednisone present in breast milk are very low 1 . In fact, no adverse effects have been observed in breastfed infants from mothers who have used any corticosteroid during breastfeeding, including prednisone.
Despite some suggestions to avoid breastfeeding for four hours after a dose, this isn’t typically necessary due to the low concentrations of prednisone in milk. That being said, high doses of prednisone might occasionally lead to a temporary decrease in milk supply.
As always, it's crucial to discuss any medication use with your healthcare provider to ensure it's suitable for both you and your baby.